Apr 10, 2025

In this episode, Dr. JYP talks with Dr. J. Harrison Howard, a surgical oncologist who specializes in melanoma. Dr. Howard explains that not all skin cancers are the same, emphasizing that melanoma is more dangerous compared with basal cell and squamous cell carcinomas. He highlights the importance of detecting melanoma early, as it is the most dangerous form of skin cancer.

They discuss surgical and systemic treatment advancements, including the practice of sentinel lymph node biopsy and the game-changing benefits of immunotherapy. Dr. Howard says clinical trials are essential in improving treatment methods and increasing survival rates. He stresses the necessity of regular follow-ups for melanoma patients to catch any recurrence early. Lastly, Dr. Howard and Dr. JYP discuss skin cancer prevention, recommending sunscreen, protective clothing, and annual dermatologist visits to reduce the risk.

3 Key Takeaways


1. Diversity in skin cancer types: Not all skin cancers are created equal. Dr. Howard emphasizes the differences among various types of skin cancer, with a specific focus on melanoma. While basal cell carcinoma and squamous cell carcinoma are often treatable with surgery and have high cure rates, melanoma can quickly become life-threatening if not caught early. The depth of melanoma in the skin is critical, and it can spread and become fatal.

2. Advancements in melanoma treatment: There are exciting developments in both surgical and systemic treatments for melanoma. Dr. Howard talks about the trend toward less invasive surgery and the success of sentinel lymph node biopsy – developed by his late mentor, Dr. Donald Morton – as a significant advancement in minimizing side effects. Furthermore, systemic treatments such as immunotherapy are proving to be game-changing as they drastically improve survival rates for stage 4 melanoma.

3. Prevention and follow-up: The importance of prevention and regular monitoring is heavily emphasized. Sunscreen, protective clothing, and regular skin check-ups are crucial in reducing the risk of skin cancer. Dr. Howard also underscores that once someone has had melanoma, the risk of another melanoma greatly increases, necessitating lifelong vigilance and regular dermatologist visits to detect any cancers or pre-cancers early.

Show Overview

00:00   Basal cell and squamous cell carcinomas

05:08   Melanoma increases future risk tenfold 

07:43   Development of sentinel lymph node biopsy 

12:17   Redefining melanoma surgery 

15:49  Clinical trials explained

17:43  To clinical trial participants: “You’re a hero.”

22:34  SPF-infused clothing for sun protection, and more